No doubt loss of production time can be very costly. A well known fact that is usually tackled with the use of contractual penalties. But this can be a two edged sword, building in a hurry can have a negative impact on quality.
Usually pharmaceuticals deal with both issues, time and quality, by means of the appropriate contract agreements. Instead of using fixed price agreement they resort to the Project Management contract type. The use of established PM companies works well, here they get the needed time and quality results. Pharmaceutical construction jobs are usually of relatively short duration because of the huge cost on loss of production days that will never be recovered. The success of the job is not automatically solved by magic scheduling, the selection of the contract type as well as the team of PM and Contractors is also critical.
Anyway, from the point of view of the Owner of the job frequently he shall analyze the time impact on his job and manage the job with this consideration. Time is money and the consideration of planning activities and entire jobs shall considering time dependent availability of funds, the inflation impact on cost as well as the impact on net present value and the internal rate of return. They need software capable of assisting them with such analysis.
http://www.pmknowledgecenter.com/node/104
Doubly constrained resources are constrained on a periodic basis, similar to renewable resources, as well as for the total project duration, as with the consumable resources. An example is a total budget with an extra restriction of a maximum limit per period.
These resource types cannot be modeled in any way using the traditional resource types, make sure your software is capable enough.
Best Regards,
Rafael